Macon County sits at the crossroads of two of Missouri's roads of the future, Highway 63 and 36. Highway 63 is an important four lane north-south artery linking southeast and northeast Missouri and Highway 36 is an important four lane east-west connection from Chicago to Kansas City. Macon is an hour's drive from Interstate 70 and is easily accessible to most major markets throughout the United States.
Macon was one of the first Missouri towns to receive a designated Enterprise Zone that offers special incentives to business and industry locating in Macon.
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